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They found the healthy mice experienced problems with their eyes for about two days. However the drug affected the vision of mice who carried the mutant gene for two weeks. The researchers also found early signs that the cells in the mice's eyes were dying, suggesting sildenafil may cause loss of vision in people who carry the gene for the disease but have normal vision. Dr Lisa Nivison-Smith, of the UNSW School of Optometry and Vision Science, said: 'If cells actually die in the retina that would lead to blindness. ' People who have normal vision, but who carry a single copy of the mutant gene for retinitis pigmentosa, could be more susceptible to changes caused by sildenafil, she added.

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