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1,2 Both belong to a class of medicines known as phosphodiesterase type 5 (PDE5) inhibitors. PDE5 inhibitors work only in the presence of sexual stimulation, as they rely on the natural release of nitric oxide (NO), a chemical only released during sexual arousal. NO in turn activates other substances to relax the smooth muscle inside the penis to allow the inflow of blood and an erection to occur. 1,2,3 PDE5 inhibitors enhance the effect of NO. 1,2. Which drug was first approved and which one lasts for longer. On March 27, dtada, Viagra became que es viagra soft gel first oral pill, and the first PDE5 inhibitor, to be approved by the FDA to treat ED. 4 A generic for Viagra is expected to be available December 2017. Cialis was first approved for ED on November 21st, 2003.

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Regards pledge. It is safe for you to take Viagra with Lisinopril providing your blood pressure is well controlled. Check with your doctor.

Erectile Dysfunction Guide. further reading. Today on WebMD. Can You Avoid ED.]