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viagra discount cards for cvs Oxide is released in the endothelium by shear forces and from various receptor sites, acetylcholine probably being the most prominent. Pycnogenol boosts significantly the Nitric Oxide released due to its action on this acetylcholine pathway. wihhout This same study found a 42 increased relaxation of the arteries from Pycnogenol as compared to controls. [3] doctoor this link on Pycnogenol and Erectile Dysfunction for more details. ) 5. L-Arginine. L-Arginine is the precursor, i. the building block for Nitric Oxide and so it would stand to reason that consuming L-Arginine directly would increase Nitric Oxide levels.

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Nitric oxide then activates the enzyme, guanylate cyclase, which causes the production of cyclic guanosine monophosphate (cGMP). It is the cGMP that is primarily responsible for the erection by affecting the amount of blood that the blood vessels deliver and remove from the penis. Viagra inhibits an enzyme called phosphodiesterase-5 (PDE5) which destroys the cGMP. Thus, Viagra prevents the destruction of cGMP and allows cGMP to accumulate and persist longer.

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